Ovarian Cancer

28/05/2013 by admin | Gynecologic Cancer

 

  1. o 90% epithelial
  2. o Other common = Papillary serous cystadenocarcinoma and adenocarcinoma.
  3. o OC linked to BRCA1 and 2 genes, HRT and high oestrogen status (ie early menarche & late menopause) are at increased risk.
  4. o Few early clinical signs – p/c abdominal distension, ascites, bladder/bowel disturbances, bloating, backpain, fatigue, incontinence, retention.
  5. o Diagnosis via: pelvic exam, transvaginal USS, and CA-125 markers.
  6. o Confirm with surgical inspection and biopsy.
  7. o Prevention = Tubal ligation and hysterectomy reduce the risk and removal of both tubes and ovaries (bilateral salpingo-oophorectomy) dramatically reduces the risk of not only ovarian cancer but breast cancer also.
  8. o Tx via surgical adjuvant CT/RT. 
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