21/06/2013 by admin | Rheumatology
  1. Is the impaired mineralization (deposition of hydroxyapatite) of bone in the mature skeleton. Due to inadequate phosphate and or calcium in the extracellular fluid, or a circulating inhibitor of mineralization



  1. Vitamin D deficiency.
  2. Abnormal vitamin D metabolism – liver/renal disease or drugs such as anticonvulsants, hypophosphatemia.
  3. Inhibitors of mineralization: aluminium, bisphosphanates, fluoride.


P/c: pain and deformity of long bones and pelvis (myopathy).

Ix: elevated alk. phos. reduced 25 hydroxyvitamin D, low urinary calcium, high urinary phosphate.

Tx: Vitamin D replacement 

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