Classification / type of disease:
There are two morphological types:
- Classical (brain stem) Lewy bodies are an eosinophilic cytoplasmic inclusion that consists of a dense core surrounded by a halo of 10-nm wide radiating fibrils, the primary structural component of which is alpha-synuclein.
- Cortical Lewy bodies are less well defined and lacks the halo. Nonetheless, it is still made up of alpha-synuclein fibrils.
- Cortical Lewy bodies are a distinguishing feature of Dementia with Lewy bodies (DLB) and may occasionally be seen in ballooned neurons characteristic of Pick’s disease and corticobasal degeneration
- A Lewy body is composed of the protein alpha-synuclein associated with other proteins such as ubiquitin, neurofilament protein, and alpha B crystallin. Tau proteins may also be present, and Lewy bodies may occasionally be surrounded by neurofibrillary tangles