• Diabetes Insipidus (DI)

    by  • 02/08/2013 • Endocrine, Miscellaneous Endocrine Disorders

    1. Is the passage of large volumes of inappropriately diluted urine in the presence of concentrated plasma – due to reduced secretion or reduced efficacy of ADH (released from posterior pituitary)
    2. It is uncommon, is linke to polyuria (>2.5L/d) and polydipsia and must NOT be due to..
    3. DM or renal failure
    4. Primary psychogenic polydipsia
    5. Types of DI:
      1. o Cranial DI: relative or absolute ADH deficiency. Causes: familial, idiopathic, trauma to hypothalamo-pituitary region, surgical, infiltration of posterior pituitary/hypothalamus (secondary deposits/sarcoid), infections (TB, meningitis)
      2. o Nephrogenic DI: renal resistance to ADH. Causes: lithium toxicity, familial, post-obstructive uropathy, hypokalaemia/hypercalcaemia, SCA, amyloid.
    6. Tx: unrestricted access to fluids and desmopressin (long-acting analogue of ADH). 
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