Cervical Intraepithelial Neoplasia (CIN)
by admin • 28/05/2013 • Gynecologic Cancer
- RF: HPV 16 and 18, lower socioeconomic status, multiple sexual partners.
- P/c: post-coital bleeding in younger female (median age 52), later = menorrhagia, flank/leg pain.
- Prevention and diagnosis: regular pap smears (reduces womans risk of death by CIN by 90%)
- Pathology:
- 10 75-80% = squamous cell carcinoma
- 11 20-25% = adenocarcinomas (more difficult to detect)
- 12 travels via lymphatic and haemotogenous spread
- Staging: clinically staged = I – IV
- Tx: depends on stage. Worse stage = more aggressive treatment.
- Cone biopsy or simple hysterectomy
- Radical hysterectomy
- Primary chemoradiation therapy
- Palliative CT and directed RT
- Palliation = cisplatin and topotecan