Neoplastic heart disease
- Primary cardiac tumours
- Extremely rare.
- Increased risk of emboli/DVT/PE in neoplastic patients!
- 25% of primary cardiac tumours.
- Presentation at any age but mostly in adults
- 75% occur in left atrium.
- Can be polyploid or pedunculated masses, arising from undifferentiated connective tissue in the subendocardial layer.
- If pedunculated, the tumour mass may have limited movement within the heart chamber, sufficient to periodically occlude cardiac output.
- 50% patients show signs of mitral valve disease
- Masses can fragment and produce emboli
- Usually occur in interatrial septum
- Well circumscribed, poorly encapsulated adipose tissue
- Filamentous projections found in right sided valve in children and left sided valves in adults.
- Composed of connective tissue with smooth muscle and fibroblasts.
- Occur in neonates causing stillbirth or death in the first few days of life.
- Often multiple and arise from cardiac muscle.
- Strand in the cytoplasm radiating out of the nucleus = spider cells