• Archive for October, 2013

    Eponymous Syndromes S-Z

    by  • 25/10/2013 • Eponymous Syndromes

     Sister Mary Joseph nodule  Sjogren’s syndrome  Stevens-Johnson syndrome  Sturge-Weber syndrome  Takayasu’s arteritis (aka Aortic arch syndrome/pulseless disease)  Tietze’s syndrome  Todd’s palsy  Vincent’s angina  Von Hippel-Lindau syndrome:  Von Willebrand’s disease (vWD)  Wallenberg’s lateral medullary syndrome  Waterhouse-Friderichsen’s (WhF) syndrome  Weber’s syndrome  Wegener’s...

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    Eponymous Syndromes M-R

    by  • 23/10/2013 • Eponymous Syndromes

     McArdle’s glycogen storage disease (type V)  Mallory-Weiss tear  Marchiafava-Bignami syndrome  Marchiafava-Micheli syndrome  Marfan’s syndrome  Meckel’s diverticulum  Meig’s syndrome  Menetrier’s syndrome  Meyer-Betz syndrome  Mikulicz’s syndrome  Milroy’s syndrome  Munchausen’s syndrome  Ortner’s cardiovocal syndrome  Osler-Weber-Rendu syndrome  Paget’s disease of the breast ...

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    Eponymous Syndromes G-L

    by  • 22/10/2013 • Eponymous Syndromes

     Gardner’s syndrome  Gelineau’s syndrome (narcolepsy)  Gerstmann’s syndrome  Gilbert’s syndrome  Gilles de la Tourette syndrome  Goodpasture’s disease  Guillain-Barre syndrome  Henoch-Schonlein purpura (HSP)  Horner’s syndrome  Huntington’s chorea  Jervell-Lange-Nielsen syndrome  Kaposi’s sarcoma  Klippel-Trenaunay syndrome  Korsakoff’s syndrome  Leriche’s syndrome  Loffler’s eosinophilic carditis...

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    Thrombophilia (and hypercoagulation)

    by  • 21/10/2013 • Haematology

    Definition: the propensity to develop thromboses due to a hereditary defect of clotting factors.   Classification / type of disease: Epidemiology: typically 5-8% of popn have a thrombophilic state, but only addition of other risk factors will lead pt to suffer symptoms Presenting symptoms / signs: DVT, PE, VTE, MI, CVA, portal vein thrombosis,...

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    Eponymous Syndromes A-F

    by  • 21/10/2013 • Eponymous Syndromes

     Alice in wonderland syndrome (Todd’s syndrome)  Arnold-Chiari malformation  Baker’s cysts  Barrett’s oesophagus  Bazin’s disease  Behcet’s disease  Berger’s disease  Bickerstaff’s brainstem encephalitis (related to Miller-Fisher syndrome)  Brugada syndrome  Brown-sequard syndrome  Budd-Chiari syndrome  Buerger’s disease  Caplan’s syndrome  Charcot-Marie-Tooth syndrome  Churg-Strauss syndrome...

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    by  • 19/10/2013 • Haematology

    Definition: a group of hereditary genetic disorders that impair the coagulation cascade.   Classification / type of disease:   Haemophilia A (clotting factor VIII deficiency) is the most common form of the disorder, occurring at about 1 in 5,000–10,000 male births. =80% of haemophilia cases. Often present before age 2yo, unaffected PTT, prolonged APTT.   Haemophilia...

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    by  • 18/10/2013 • Haematology

    Process of cessation of bleeding, based on primary haemostasis (platelet mediated) and secondary haemostatic processes (coagulation factors). Disorders of coagulation can lead to excessive bleeding (haemophillic state) or excessive clotting (throbothillic state). Platelet activation: InjuryvWF released from subendotheliumrecruits factor VIII and collagenplatelets bind to collagen which express surface specific glycoprotein Ia/IIa receptors (further strengthened...

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    Chronic granulytic leukaemia

    by  • 18/10/2013 • Haematology

    Myelodysplastic syndrome (pre-leukaemic state) = refractory anaemia +/- myeloblasts, chronic myelomonocytic leukaemia. Myelodysplastic sydrome = are a diverse collection of hematological conditions united by ineffective production of myeloid blood cells and risk of transformation to acute myelogenous leukemia (AML). Signs/symptoms: anaemia, neutropaenia, thrombocytopaenia, spplenomegally, can be asymptomatic. RFs include radiation and benzene. Tx: focus on redcuing risk of progression onto...

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    Hodgkins and non-hodgkins lymphoma

    by  • 17/10/2013 • Haematology

    Hodgkins lymphoma: unlike other lymphomas – has a bimodal age distribution (15-35, >55yo). Hodgkins is characterized by the spread of disease from one lymph node group to another and by the development of systemic symptoms with advanced disease. Histopath typically shows multinucleated Reed-Sternberg cells. Staging involves thorough imaging (CT, MRI, PET – plus biopsy) and is by the Ann...

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    by  • 16/10/2013 • Haematology

    Cells differentiate from a pluripotent haemopoietic stem cell Normal haemopoiesis = proliferationdifferentiationapoptosis Neoplasic change in cascade = leukaemia (cancer of WBC/BM) Uncontrolled proliferation by either: excessive proliferation of resistance to apoptosis Acute L: short, aggressive, easier to tx and so better outcome Chronic L: indolent, refractory and worse outcome. Causes: chemicals (benzenes, smoking, alcohol,...

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